惡性腦瘤的治療.pdf

• 15% CNS tumors are in the spinal cord, 85% in the brain
• Metastatic tumors are usually extradural
• Account for 2% of all cancer deaths, but ~20% of cancer deaths before age 15 (second only to leukemias)
• Most are idiopathic; radio waves from cellular phones have been implicated by some
• CNS tumors seen with von Recklinghausen's, von Hippel-Lindau, Turcot's familial polyposis, tuberous sclerosis, and the multiple nevoid basal cell carcinoma syndromes
• 70% of intracranial tumors are supratentorial in adults (most commonly astrocytomas [40-50%], metastases, meningiomas[~15%]), but 70% are infratentorial in children (most commonly astrocytoma [45%], medulloblastoma [40%], ependymoma, and craniopharyngioma)
• Even benign tumors can be lethal; lethality more commonly caused by compression and herniation rather than actual destruction of brain tissue by the tumor itself
• Rarely metastasize out of CNS