- Scarring of the entire liver with diffuse fibrosis, loss of lobular architecture, and nodular regeneration
- Final common pathway for many diseases—often, the specific etiology cannot be determined histologically
- Vascular reorganization with formation of abnormal arteriovenous connections is common
- Ductular proliferation is seen regardless of etiology; does not necessarily indicate PBC
- It is important to evaluate the level of activity: look for ongoing necrosis at border between septa and parenchyma