- More frequent in females (3-4:1)
- 90% of patients >50 yr old
- May be diffuse (70%) or polypoid (30%) mass
- 80-90% of cases also have gallstones
- Diffuse form may be grossly indistinguishable from chronic cholecystitis
- Most are adenocarcinomas
- Most have invaded the liver by time of diagnosis (stage V); uniformly fatal